 ProjectsFunction, relevance and analysis of shifts in GI- microbiota in the metablic syndrom and due to dietFFG, startedPublic Health Genomics, PHGENEU- Framework projecthttp://www.phgen.eu/typo3/index.php The project wants to establish fundamentals for the use of molecular analysis in public health Cell activation and signalling of probiotic bacteriaSapientiaThe project analysis TLR activation, signanlling cascades and epigenetic regulation by probiotic cells recent project:Fundamentals for a nutritional counselling for use of probiotics FWF Fermented milk and probiotic Lactic Acid Bacteria have been claimed to prolong life since Elie Metchnikoff and Minoru Shirota. Intensive scientific research, efforts from industry, economic success of products as well as public concern about industrial health claims have characterised the development of probiotic products for use in many health areas and disease prevention. The discovery and analysis of the human gastrointestinal (GI) microbiome by modern molecular methods based on culture free analysis of microorganisms has shown individual, lifestyle- and nutrition relevant characteristics of the microbiome as well as microbiome linked individual susceptibilities for diseases such as allergies, obesity, inflammatory or nervous diseases. In parallel probiotic products were diversified for uses in these different diseases and prevention situations. In combination with genetic, epigenetic, nutritional and environmental factors, evaluated e.g. by questionnaires, characteristics of the microbiome are an important element of an individual, preventive health care (such as addressed by the Public Health Genomic EU research network, where our working group participates). Objective of the project was to establish fundamentals for a nutritional counselling for the use of probiotics in different health scenarios. This would be achieved by an analysis of the scientific progress in the field, by the development of methods for an analysis of nutritional characteristics and faecal microbiota of consumers, interested in a counselling for a potential science based use of a probiotic product. The project established and published guidance for effects and uses of nutrition and probiotics in different diseases, specific questionnaires, methods for cost adequate analysis of individual’s faecal microbiota as an indicator for the situation of the GI microbiota. Addressing the requirement of a translational project counselling started at the end of the project (http://www.healthbiocare.com). Clearly the discussions on the relevance of the GI microbiome for obesity after the start of the project boostered and influenced the project. Most importantly the project built a solid basis for the integration of new developments from the rapid scientific progress for the uses of nutritional counselling. The concept of nutrition linked enterotypes might contribute to shape nutritional sciences. Publications and presentations at international meetings included the role of nutrition on anti-inflammatory short chain fatty acid producing microbiota, consequences of nutrition, chemotherapy, antibiotics on microbiota and probiotic/antibiotic combinations for antibiotic associated diarrhoea. Probiotics in immune suppressed patients Nationalbank The projects established expereinces of changes in GI microbiota im immune compromised patients Probiotic bacteria in organic salad Lebensministerium The project showed differences of bacteria in the phyllosphere of organic grown lettuce |
